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GLP-1 half-life calculator: how a dose fades after you take it

A half-life is the time it takes for half of a dose to clear.

≤ 365 d

This follows one dose. Regular doses overlap, so the real level builds up over time.

Your numbers will appear here

Enter your own details to see the arithmetic. The examples below are made up.

How this works

The math

How it works

percent left = 100 × 0.5 ^ (hours since dose ÷ half-life in hours)
MedicineLabel saysUsed here
Semaglutide (Wegovy, Ozempic, Wegovy pill, Ozempic pill, Rybelsus)About 1 week12168 hours
Tirzepatide (Zepbound, Mounjaro)About 5 days, or 5 to 6 days in people with overweight or obesity34120 hours
Orforglipron (Foundayo)About 29 to 49 hours539 hours

The values used here are illustrative model choices: 120 hours uses the low end of the tirzepatide range, and 39 hours is the midpoint of 29 to 49 hours. Your body may clear a medicine faster or slower. The same constants power the medication level in the Onederland app.

Before you act on this

This is an estimate, not a lab test, and it can’t tell you when a medicine is gone. Don’t use it to time a dose.

Planning a pregnancy or surgery? Tell your prescriber and your surgical team what you take and when you last took it. The Wegovy label, for example, says to stop at least 2 months before a planned pregnancy.1

Always follow your doctor’s or prescriber’s advice and guidance. Talk to your prescriber before changing your dose.

For information only, not medical advice. Verify results with your healthcare provider; Onederland accepts no liability for use of these tools.

  • Runs on this device. Nothing you type is sent anywhere.
  • Every figure names its source, below.
  • Education, not medical advice. Your prescriber comes first.
Sources

Sources

  1. Wegovy (semaglutide) injection and tablets, US prescribing information, revised 06/2026. accessdata.fda.gov
  2. Ozempic (semaglutide) injection, US prescribing information, revised 05/2026. accessdata.fda.gov
  3. Zepbound (tirzepatide) injection, US prescribing information, revised 08/2026. accessdata.fda.gov
  4. Mounjaro (tirzepatide) injection, US prescribing information, revised 08/2026. accessdata.fda.gov
  5. Foundayo (orforglipron) tablets, US prescribing information, revised 07/2026. dailymed.nlm.nih.gov

Label sources last checked on November 8, 2026. Onederland summarizes them; your prescriber and the full prescribing information come first.

About half-life

How long does semaglutide stay in your body?

The Ozempic label says about 5 weeks after the last dose, and the Wegovy label says about 5 to 7 weeks after the last 2.4 or 7.2 mg dose.

Is this the same as my medication level?

Not quite. This follows one dose. Your medication level adds up all your recent doses, which the Onederland app estimates from the doses you log.

Will side effects fade at the same pace?

Not necessarily. If a side effect is severe or doesn’t ease, contact your care team.

Published by Micktron LLC · Sources checked October 30, 2026

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