How this works
The math
Why medicines step up
Labels start low and go up slowly to reduce the risk of stomach and gut side effects. The starting dose is usually for getting used to the medicine, not for long-term use.1
A label gives the least time at a step. It doesn’t say you have to move up. If a dose is hard to tolerate, labels tell prescribers to consider a slower pace or a lower dose.12
What the label shows
These are adult label tables. Children and adolescents can have different dose limits.
US
Wegovy2
| Dose | Minimum time | Role on the label |
|---|---|---|
| 0.25 mg | 4 weeks | Starting dose |
| 0.5 mg | 4 weeks | Step |
| 1 mg | 4 weeks | Step |
| 1.7 mg | 4 weeks | Maintenance |
| 2.4 mg | 4 weeks | Maintenance |
| 7.2 mg | Ongoing | Highest dose |
The 7.2 mg dose is only for adult weight reduction, after tolerating 2.4 mg for at least 4 weeks and when further weight reduction is clinically indicated. For cardiovascular risk reduction, maintenance is 2.4 mg (recommended) or 1.7 mg weekly. For noncirrhotic MASH with moderate to advanced fibrosis, maintenance is 2.4 mg weekly; 1.7 mg may be used if 2.4 mg is not tolerated.2
Ozempic3
| Dose | Minimum time | Role on the label |
|---|---|---|
| 0.25 mg | 4 weeks | Starting dose |
| 0.5 mg | 4 weeks | Maintenance |
| 1 mg | 4 weeks | Maintenance |
| 2 mg | Ongoing | Highest dose |
This label is for type 2 diabetes. These are not weight-loss dose steps.
These are glycemic-control steps. The US label also covers cardiovascular risk reduction in adults with type 2 diabetes and established cardiovascular disease, and kidney and cardiovascular risk reduction in adults with type 2 diabetes and chronic kidney disease. For the kidney indication, maintenance is 1 mg weekly after at least 4 weeks on 0.5 mg.3
Zepbound1
| Dose | Minimum time | Role on the label |
|---|---|---|
| 2.5 mg | 4 weeks | Starting dose |
| 5 mg | 4 weeks | Maintenance |
| 7.5 mg | 4 weeks | Step |
| 10 mg | 4 weeks | Maintenance |
| 12.5 mg | 4 weeks | Step |
| 15 mg | Ongoing | Highest dose |
The US label lists 5 mg, 10 mg, or 15 mg once weekly as maintenance doses for weight reduction and long-term maintenance. For obstructive sleep apnea, the maintenance doses are 10 mg or 15 mg once weekly. This table does not choose a dose.1
Mounjaro4
| Dose | Minimum time | Role on the label |
|---|---|---|
| 2.5 mg | 4 weeks | Starting dose |
| 5 mg | 4 weeks | Step |
| 7.5 mg | 4 weeks | Step |
| 10 mg | 4 weeks | Step |
| 12.5 mg | 4 weeks | Step |
| 15 mg | Ongoing | Highest dose |
This label is for type 2 diabetes. These are not weight-loss dose steps.
The US label covers glycemic control and cardiovascular risk reduction in eligible adults with type 2 diabetes. Dose increases are based on a need for additional glycemic control; there is no separate cardiovascular dose schedule.4
Wegovy pill2
| Dose | Minimum time | Role on the label |
|---|---|---|
| 1.5 mg | 30 days | Starting dose |
| 4 mg | 30 days | Step |
| 9 mg | 30 days | Step |
| 25 mg | Ongoing | Maintenance |
The US tablet schedule applies to weight reduction and cardiovascular risk reduction in eligible adults, with 25 mg daily as maintenance. The MASH indication is for the injection.2
Ozempic pill5
| Dose | Minimum time | Role on the label |
|---|---|---|
| 1.5 mg | 30 days | Starting dose |
| 4 mg | 30 days | Maintenance |
| 9 mg | Ongoing | Highest dose |
This label is for type 2 diabetes. These are not weight-loss dose steps.
The US tablet label also covers cardiovascular risk reduction in adults with type 2 diabetes at high cardiovascular risk. It uses the same schedule, with increases based on a need for additional glycemic control.5
Rybelsus5
| Dose | Minimum time | Role on the label |
|---|---|---|
| 3 mg | 30 days | Starting dose |
| 7 mg | 30 days | Maintenance |
| 14 mg | Ongoing | Highest dose |
This label is for type 2 diabetes. These are not weight-loss dose steps.
The US tablet label also covers cardiovascular risk reduction in adults with type 2 diabetes at high cardiovascular risk. It uses the same schedule, with increases based on a need for additional glycemic control.5
Foundayo6
| Dose | Minimum time | Role on the label |
|---|---|---|
| 0.8 mg | 30 days | Starting dose |
| 2.5 mg | 30 days | Step |
| 5.5 mg | 30 days | Step |
| 9 mg | 30 days | Step |
| 14.5 mg | 30 days | Step |
| 17.2 mg | Ongoing | Highest dose |
EU
Wegovy7
| Dose | Minimum time | Role on the label |
|---|---|---|
| 0.25 mg | 4 weeks | Starting dose |
| 0.5 mg | 4 weeks | Step |
| 1 mg | 4 weeks | Step |
| 1.7 mg | 4 weeks | Step |
| 2.4 mg | 4 weeks | Maintenance |
| 7.2 mg | Ongoing | Maintenance |
For adults, the EU label permits the 7.2 mg maintenance dose only when BMI was at least 30 at treatment initiation, after at least 4 weeks on 2.4 mg. This table does not choose a dose.7
Ozempic8
| Dose | Minimum time | Role on the label |
|---|---|---|
| 0.25 mg | 4 weeks | Starting dose |
| 0.5 mg | 4 weeks | Maintenance |
| 1 mg | 4 weeks | Maintenance |
| 2 mg | Ongoing | Highest dose |
This label is for type 2 diabetes. These are not weight-loss dose steps.
Mounjaro9
| Dose | Minimum time | Role on the label |
|---|---|---|
| 2.5 mg | 4 weeks | Starting dose |
| 5 mg | 4 weeks | Maintenance |
| 7.5 mg | 4 weeks | Step |
| 10 mg | 4 weeks | Maintenance |
| 12.5 mg | 4 weeks | Step |
| 15 mg | Ongoing | Maintenance |
The EU label covers type 2 diabetes and weight management. The adult schedule is shared, with 5 mg, 10 mg or 15 mg weekly as maintenance doses.9
Wegovy pill7
| Dose | Minimum time | Role on the label |
|---|---|---|
| 1.5 mg | 4 weeks | Starting dose |
| 4 mg | 4 weeks | Step |
| 9 mg | 4 weeks | Step |
| 25 mg | Ongoing | Maintenance |
Rybelsus10
Label schedule starting at 1.5 mg
| Dose | Minimum time | Role on the label |
|---|---|---|
| 1.5 mg | 1 month | Starting dose |
| 4 mg | 1 month | Maintenance |
| 9 mg | 1 month | Maintenance |
| 25 mg | 1 month | Maintenance |
| 50 mg | Ongoing | Maintenance |
Label schedule starting at 3 mg
These are separate label schedules, not a milligram-for-milligram conversion. The current EU product information describes the 25 mg and 50 mg tablets as oval.10
| Dose | Minimum time | Role on the label |
|---|---|---|
| 3 mg | 1 month | Starting dose |
| 7 mg | 1 month | Maintenance |
| 14 mg | 1 month | Maintenance |
| 25 mg | 1 month | Maintenance |
| 50 mg | Ongoing | Maintenance |
This label is for type 2 diabetes. These are not weight-loss dose steps.
Japan
Wegovy11
| Dose | Minimum time | Role on the label |
|---|---|---|
| 0.25 mg | 4 weeks | Starting dose |
| 0.5 mg | 4 weeks | Step |
| 1 mg | 4 weeks | Step |
| 1.7 mg | 4 weeks | Step |
| 2.4 mg | Ongoing | Maintenance |
The Japanese label covers obesity and noncirrhotic MASH with moderate or advanced fibrosis. Both use the same adult escalation to 2.4 mg weekly; the dose may be reduced according to the patient’s condition.11
Ozempic12
| Dose | Minimum time | Role on the label |
|---|---|---|
| 0.25 mg | 4 weeks | Starting dose |
| 0.5 mg | 4 weeks | Maintenance |
| 1 mg | Ongoing | Highest dose |
This label is for type 2 diabetes. These are not weight-loss dose steps.
Zepbound13
| Dose | Minimum time | Role on the label |
|---|---|---|
| 2.5 mg | 4 weeks | Starting dose |
| 5 mg | 4 weeks | Maintenance |
| 7.5 mg | 4 weeks | Step |
| 10 mg | 4 weeks | Maintenance |
| 12.5 mg | 4 weeks | Step |
| 15 mg | Ongoing | Highest dose |
For obesity, the Japanese label describes 10 mg as the usual dose after escalation, with 5 mg or up to 15 mg according to the patient’s condition. The steps here do not choose a dose for you.13
For moderate to severe obstructive sleep apnea, the Japanese label uses escalation to 15 mg weekly, with adjustment within 10–15 mg if not tolerated. The obesity dose description above is not the sleep-apnea schedule.13
Mounjaro14
| Dose | Minimum time | Role on the label |
|---|---|---|
| 2.5 mg | 4 weeks | Starting dose |
| 5 mg | 4 weeks | Maintenance |
| 7.5 mg | 4 weeks | Step |
| 10 mg | 4 weeks | Step |
| 12.5 mg | 4 weeks | Step |
| 15 mg | Ongoing | Highest dose |
This label is for type 2 diabetes. These are not weight-loss dose steps.
Rybelsus15
| Dose | Minimum time | Role on the label |
|---|---|---|
| 3 mg | 4 weeks | Starting dose |
| 7 mg | 4 weeks | Maintenance |
| 14 mg | Ongoing | Highest dose |
This label is for type 2 diabetes. These are not weight-loss dose steps.
Before you act on this
Talk to your prescriber before changing your dose. This page can’t tell you which step is right for you, or when to move.
Always follow your doctor’s or prescriber’s advice and guidance. Talk to your prescriber before changing your dose.
For information only, not medical advice. Verify results with your healthcare provider; Onederland accepts no liability for use of these tools.
- Runs on this device. Nothing you type is sent anywhere.
- Every figure names its source, below.
- Education, not medical advice. Your prescriber comes first.
Sources
Sources
- Zepbound (tirzepatide) injection, US prescribing information, revised 08/2026. accessdata.fda.gov
- Wegovy (semaglutide) injection and tablets, US prescribing information, revised 06/2026. accessdata.fda.gov
- Ozempic (semaglutide) injection, US prescribing information, revised 05/2026. accessdata.fda.gov
- Mounjaro (tirzepatide) injection, US prescribing information, revised 08/2026. accessdata.fda.gov
- Rybelsus and Ozempic (semaglutide) tablets, US prescribing information, revised 01/2026. accessdata.fda.gov
- Foundayo (orforglipron) tablets, US prescribing information, revised 07/2026. dailymed.nlm.nih.gov
- EU product information for semaglutide for weight management (tablets: summary of product characteristics, section 4.2), updated 21 September 2026. ema.europa.eu
- EU product information: injectable semaglutide for type 2 diabetes. ema.europa.eu
- EU product information: tirzepatide. ema.europa.eu
- EU product information: oral semaglutide for type 2 diabetes. ema.europa.eu
- Japanese prescribing information: injectable semaglutide for obesity, June 2026. pmda.go.jp
- Japanese patient medicine guide: injectable semaglutide for type 2 diabetes, March 2024. info.pmda.go.jp
- Japanese prescribing information: tirzepatide for obesity, September 2026. pmda.go.jp
- Japanese prescribing information: tirzepatide for type 2 diabetes. medical.lilly.com
- Japanese patient medicine guide: oral semaglutide for type 2 diabetes, March 2024. info.pmda.go.jp
Label sources last checked on October 30, 2026. Onederland summarizes them; your prescriber and the full prescribing information come first.
